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| Friday, October 12, 2012 |
| Berkeley Springs at Clear Spring, MD | 7:00 p.m. |
| Bishop Donahue at Paden City | 7:30 p.m. |
| Bluefield at Westside | 7:30 p.m. |
| Brooke at Parkersburg South | 7:30 p.m. |
| Buffalo at Calhoun County | 7:30 p.m. |
| Cabell Midland at Capital | 7:30 p.m. |
| Cameron at Clay-battelle | 7:30 p.m. |
| East Fairmont at Preston | 7:30 p.m. |
| East Hardy at Moorefield | 7:30 p.m. |
| Fairmont Senior at Lincoln | 7:30 p.m. |
| Fayetteville at Mount View | 7:30 p.m. |
| George Washington at Riverside | 7:30 p.m. |
| Grafton at Liberty (Harrison) | 7:30 p.m. |
| Greenbrier West at Webster County | 7:30 p.m. |
| Hampshire at Musselman | 7:00 p.m. |
| Hannan at Betsy Layne, KY | 7:30 p.m. |
| Huntington at Logan | 7:30 p.m. |
| Hurricane at Greenbrier East | 7:30 p.m. |
| Jefferson at Keyser | 7:00 p.m. |
| Liberty (Raleigh) at Independence | 7:30 p.m. |
| Lincoln County at Nicholas County | 7:30 p.m. |
| Madonna at Notre Dame | 7:30 p.m. |
| Martinsburg at Patrick Henry, VA | 7:00 p.m. |
| Montcalm at Craig, Co, VA | 7:30 p.m. |
| Nitro at South Charleston | 7:30 p.m. |
| Oak Glen at East Liverpool, OH | 7:00 p.m. |
| Oak Hill at Lewis County | 7:30 p.m. |
| Parkersburg at Woodrow Wilson | 7:30 p.m. |
| Petersburg at Frankfort | 7:00 p.m. |
| Philip Barbour at Buckhannon-Upshur | 7:30 p.m. |
| Point Pleasant at Ravenswood | 7:30 p.m. |
| Princeton at Spring Valley | 7:30 p.m. |
| Ripley at St. Albans | 7:30 p.m. |
| Roane County at Man | 7:30 p.m. |
| Robert C. Byrd at North Marion | 7:30 p.m. |
| Scott at Herbert Hoover | 7:15 p.m. |
| Shady Spring at Wyoming East | 7:30 p.m. |
| Sissonville at Clay County | 7:30 p.m. |
| St. Marys at Gilmer County | 7:30 p.m. |
| Summers County at Meadow Bridge | 7:30 p.m. |
| Tygarts Valley at Pocahontas County | 7:30 p.m. |
| Tyler Consolidated at South Harrison | 7:30 p.m. |
| University at John Marshall | 7:30 p.m. |
| Valley (Wetzel) at Frontier, OH | 7:00 p.m. |
| Van at Tug Valley | 7:30 p.m. |
| Washington at Skyline, VA | 7:00 p.m. |
| Wayne at Tolsia | 7:30 p.m. |
| Wheeling Park at Elkins | 7:00 p.m. |
| Wirt County at Williamstown | 7:30 p.m. |
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| Saturday, October 13, 2012 |
| Sherman at St. Johns, OH | 12:00 p.m. |
| Valley (Fayette) at Parkersburg Catholic | 1:30 p.m. |