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| Thursday, September 13, 2012 |
| Oak Hill at Nicholas County | 7:30 p.m. |
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| Friday, September 14, 2012 |
| Braxton County at Ritchie County | 7:30 p.m. |
| Brooke at Steubenville, OH | 7:00 p.m. |
| Buffalo at Greenbrier West | 7:30 p.m. |
| Cameron at Beallsville, OH | 7:30 p.m. |
| Doddridge County at Wirt County | 7:30 p.m. |
| East Hardy at Pocahontas County | 7:30 p.m. |
| Frankfort at Berkeley Springs | 7:30 p.m. |
| Greenbrier East at Bluefield | 7:30 p.m. |
| Hampshire at Southern Garrett, MD | 7:00 p.m. |
| Herbert Hoover at Tolsia | 7:30 p.m. |
| Hundred at Clay-battelle | 7:30 p.m. |
| Huntington at Parkersburg | 7:30 p.m. |
| Hurricane at George Washington | 7:30 p.m. |
| Independence at Shady Spring | 7:30 p.m. |
| Lewis County at East Fairmont | 7:30 p.m. |
| Liberty (Raleigh) at Mount View | 7:30 p.m. |
| Lincoln at Petersburg | 7:30 p.m. |
| Lincoln County at Ripley | 7:30 p.m. |
| Logan at Johnson Cent. KY | 7:30 p.m. |
| Magnolia at River, OH | 7:00 p.m. |
| Man at River View | 7:30 p.m. |
| Martinsburg at Morgantown | 7:30 p.m. |
| Meadow Bridge at Fayetteville | 7:30 p.m. |
| Moorefield at Tucker County | 7:30 p.m. |
| North Marion at Buckhannon-Upshur | 7:30 p.m. |
| Notre Dame at Valley (Wetzel) | 7:30 p.m. |
| Oak Glen at John Marshall | 7:30 p.m. |
| Paden City at Gilmer County | 7:30 p.m. |
| Parkersburg South at Musselman | 7:30 p.m. |
| Pikeview at James Monroe | 7:30 p.m. |
| Poca at Chapmanville | 7:30 p.m. |
| Preston at Elkins | 7:30 p.m. |
| Princeton at Capital | 7:30 p.m. |
| Richwood at Midland Trail | 7:30 p.m. |
| Riverside at Winfield | 7:30 p.m. |
| Roane County at Webster County | 7:30 p.m. |
| Robert C. Byrd at Bridgeport | 7:30 p.m. |
| Scott at Sissonville | 7:30 p.m. |
| Sherman at Hannan | 7:30 p.m. |
| South Charleston at Cabell Midland | 7:30 p.m. |
| South Harrison at Williamstown | 7:30 p.m. |
| St. Albans at Nitro | 7:30 p.m. |
| St. Marys at Tyler Consolidated | 7:30 p.m. |
| Summers County at Wyoming East | 7:30 p.m. |
| Valley (Fayette) at Clay County | 7:30 p.m. |
| Wayne at Ravenswood | 7:30 p.m. |
| Weir at Grafton | 7:30 p.m. |
| Wheeling Park at University | 7:30 p.m. |
| Woodrow Wilson at Spring Valley | 7:30 p.m. |
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| Saturday, September 15, 2012 |
| Calhoun County at Parkersburg Catholic | 7:30 p.m. |
| Westside at Mingo Central | 7:30 p.m. |